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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALDH18A1
All Species:
25.76
Human Site:
Y288
Identified Species:
40.48
UniProt:
P54886
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54886
NP_001017423.1
795
87302
Y288
A
K
L
I
D
I
F
Y
P
G
D
Q
Q
S
V
Chimpanzee
Pan troglodytes
XP_001155890
796
87730
Y289
A
K
L
I
D
I
F
Y
P
G
D
Q
Q
S
V
Rhesus Macaque
Macaca mulatta
XP_001099359
795
87154
Y288
A
K
L
I
D
I
F
Y
P
G
D
Q
Q
S
V
Dog
Lupus familis
XP_534976
795
87233
Y288
A
K
L
I
D
I
F
Y
P
G
D
Q
Q
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z110
795
87278
Y288
A
K
L
I
D
I
F
Y
P
G
D
Q
Q
S
V
Rat
Rattus norvegicus
NP_001101994
795
87311
Y288
A
K
L
I
D
I
F
Y
P
G
D
Q
Q
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508419
607
66410
I155
S
G
H
V
I
T
D
I
V
E
G
K
K
V
G
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086040
815
89190
G289
L
I
D
I
F
Y
P
G
D
Q
Q
S
V
T
F
Zebra Danio
Brachydanio rerio
NP_001077015
782
85358
S274
F
Y
P
G
D
Q
Q
S
I
T
Y
G
T
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649375
776
84074
T275
A
K
L
M
H
T
Y
T
S
D
D
S
N
S
I
Honey Bee
Apis mellifera
XP_396399
732
79216
G273
V
S
V
V
I
C
N
G
T
Q
E
K
A
I
K
Nematode Worm
Caenorhab. elegans
P54889
800
86509
T290
P
S
E
N
S
G
V
T
F
G
A
N
S
K
F
Sea Urchin
Strong. purpuratus
XP_781524
752
81324
E273
K
A
A
N
W
A
L
E
R
G
C
S
V
V
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54888
726
78853
L274
I
S
K
V
L
R
G
L
R
V
G
T
L
F
H
Baker's Yeast
Sacchar. cerevisiae
P54885
456
49722
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.9
97.4
97.1
N.A.
95.3
95.2
N.A.
71.6
N.A.
84.4
82.1
N.A.
55.9
54.7
52.5
56.4
Protein Similarity:
100
94.9
98.2
98.6
N.A.
97.7
97.4
N.A.
74.9
N.A.
90.8
91.5
N.A.
70.8
69.5
69.5
73.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
N.A.
6.6
6.6
N.A.
33.3
0
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
N.A.
13.3
6.6
N.A.
53.3
26.6
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.1
38.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
7
7
0
0
7
0
0
0
0
7
0
7
0
0
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
7
0
47
0
7
0
7
7
47
0
0
0
0
% D
% Glu:
0
0
7
0
0
0
0
7
0
7
7
0
0
0
0
% E
% Phe:
7
0
0
0
7
0
40
0
7
0
0
0
0
7
14
% F
% Gly:
0
7
0
7
0
7
7
14
0
54
14
7
0
0
7
% G
% His:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
7
0
47
14
40
0
7
7
0
0
0
0
7
14
% I
% Lys:
7
47
7
0
0
0
0
0
0
0
0
14
7
14
7
% K
% Leu:
7
0
47
0
7
0
7
7
0
0
0
0
7
0
0
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
14
0
0
7
0
0
0
0
7
7
0
0
% N
% Pro:
7
0
7
0
0
0
7
0
40
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
7
0
0
14
7
40
40
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
14
0
0
0
0
0
0
% R
% Ser:
7
20
0
0
7
0
0
7
7
0
0
20
7
47
7
% S
% Thr:
0
0
0
0
0
14
0
14
7
7
0
7
7
7
0
% T
% Val:
7
0
7
20
0
0
7
0
7
7
0
0
14
14
40
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
7
7
40
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _